Neurotoxic symptoms are however rare and have only included diplopia and dyspnoea. Clinically, its venom contains presynaptic and postsynaptic neurotoxins, which generally affect the synaptic cleft (the points of information-transfer between neurons).  While several species of snakes may cause more bodily destruction than others, any of these venomous snakes are still very capable of causing human fatalities should a bite go untreated, regardless of their venom capabilities or behavioral tendencies. While spitting is typically their primary form of defense, all spitting cobras are capable of delivering venom through a bite as well. However, the etiology progresses to systemic neurotoxic and myalgic symptoms, with frequent kidney failure accompanied by acute tubular necrosis.  The bite is usually painless and difficult to see due to their small fangs. In mice, the SC LD50 for this species is 0.80 mg/kg and the average venom yield per bite is between 169 and 250 mg. Though it is responsible for many bites, only a small percentage are fatal if proper medical treatment and antivenom are given.  It is a member of the "big four" species, inflicting the most snakebites on humans in India.. Of 1280 snakes belonging to 34 species collected, one-third were dangerous, and the proportions of Viperidae, Elapidae and Atractaspidae were 23%, 11% and 0.6%, respectively. .  Due to the fact that krait venom contains many presynaptic neurotoxins, patients bitten will often not respond to antivenom because once paralysis has developed it is not reversible.  Bite symptoms include severe external hemorrhaging and tissue necrosis around the bite area and difficulty breathing. In humans, bites from this species can produce severe local and systemic symptoms. Deadly Snakes: What are the world's most deadly venomous snakes? They are slow moving, but like other Bitis species, they're capable of striking quickly, forwards or sideways, without coiling first or giving a warning. In the Middle East the species of greatest concern are carpet vipers and elapids; in Central and South America, Bothrops (including the terciopelo or fer-de-lance) and Crotalus (rattlesnakes) are of greatest concern. According to a study of fatal snakebites in rural areas of Thailand, 13 out of 46 were caused by C. rhodostoma (Looareesuwan et al. Nearly identical neurotoxins have been discovered in five North American rattlesnake species besides the Mojave rattlesnake. , Medical treatment as soon as possible after a bite is critical to a positive outcome, dramatically increasing chances for survival. Norris R. (2004). The Fer-de-lance or Terciopelo (Bothrops asper) has been described as excitable and unpredictable when disturbed. The venom of this species has the most potent composition of toxins found among any cobra species known. Although mortality rate in untreated cases is low (~5–10%), when death occurs it is usually due to asphyxiation by paralysis of the diaphragm.  This species causes an estimated 10,000 fatalities per year in India alone. Intramuscular : Venom is injected into a muscle. Cause of death is general respiratory failure, i.e. However, at night, the snake is very active and escapes by hissing loudly, or keeping still, occasionally biting the source of the annoyance. In case of severe envenomation, death can occur as early as 30 minutes after being bitten, but average death time after a bite is around 3–6 hours and it is variable, depending on various factors such as the nature of the bite and the health state of the victim.  The venom of this species also contains myotoxins and cardiotoxins. The mortality rate among untreated bite victims is nearly 100%. 1996 and the Australian venom and toxin database both list a LD50 value of 0.106 mg/kg for subcutaneous injection. If bitten by a krait while sleeping, a victim may not realize he/she has been bitten, as the bite feels like that of an ant or mosquito. Local tissue damage appears to be relatively infrequent and of minor severity in most cases of black mamba envenomation. They are the snakes with the front-fangs. Average venom yield (dry weight) is between 5–10 mg (Minton, 1974). Based on the Median lethal dose (LD50) values in mice, the black mamba LD50 from all published sources is as follows: It is estimated[by whom?] Other symptoms may include uncoordinated movements, defecation, urination, swelling of the tongue and eyelids, convulsions and unconsciousness. These animals are badly affected by stress and rarely live long in captivity. The Agkistrodon contortrix commonly known as the Copperhead is a species of venomous snake, a pit viper, endemic to Eastern North America; it is a member of the subfamily Crotalinae in the family Viperidae. It also contains weak pre-synaptic neurotoxins. It is the most venomous species of cobra in the world, slightly ahead of the Philippines cobra based on a toxinological study from 1992 found in the Indian Journal of Experimental Biology, in which this species produced the highest potency venom among cobras. They have an average venom yield of 44 mg. Bites from this species have a mortality rate of 80% if left untreated, although it is very rare for this species to bite. However, mortality rate among untreated bite victims is very low (1–10%). However, in 2008, around the area of Friguiagbé in Guinea, there were 375 bites attributed to the forest cobra and of those 79 were fatal. All three species have a tendency to strike repeatedly with little provocation, although they are generally much less aggressive than their larger cousin, the Black mamba. The fangs are the longest of any Australian elapid snake, being up to 1.2 cm (0.5 in) long, and are able to be brought forward slightly when a strike is contemplated. This may help in species identification if the snake has not been seen. Cardiotoxicity is possible, but rare. Length: The common krait grows to an average length of 0.9 m (3.0 ft), but some have been seen to grow up to 1.75 m (5 ft 9 in). The SC LD50 for this species according to Brown (1973) is 1.0 mg/kg, while the IV LD50 is 0.8 mg/kg. , The Many-banded krait (Bungarus multicinctus) is the most venomous krait species known based on toxinological studies conducted on mice. A clinical toxicology study gives an untreated mortality rate of 70-80%. Sherman A. Minton, (May 1, 1974) Venom diseases, Page 116, Philip Wexler, 2005, Encyclopedia of toxicology, Page 59, Thomas J. Haley, William O. Berndt, 2002, Toxicology, Page 446, Scott A Weinstein, David A. Warrell, Julian White and Daniel E Keyler (Jul 1, 2011) " Bites from Non-Venomous Snakes: A Critical Analysis of Risk and Management of "Colubrid" Snake Bites (page 246). The maximum wet venom yield is 200 mg. In only a few detailed reports of human envenomation, massive swelling, which may lead to necrosis, had been described. The eyes are black. The inland taipan (Oxyuranus microlepidotus) is considered the most venomous snake in the world with a murine LD50 value of 0.025 mg/kg SC. This is not a typically aggressive snake, but it will strike and hiss loudly when provoked. The venom sprays out in distinctive geometric patterns, using muscular contractions upon the venom glands. With each bite, the snake delivers anywhere from 100 to 400 mg of a rapid-acting and virulently toxic venom. The banded water cobra has one subspecies which is known as Storms water cobra (Naja annulata stormsi). These species were formerly under the genus Boulengerina. Spawls S, Howell K, Drewes R, Ashe J.  It is also the fastest striking venomous snake in the world. 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